Although having Samuel active is good news for San Francisco, bad news followed with Mitchell, who is not expected to take the field. Mitchell has recorded 16 carries for 52 yards so far this season, with the young running back not playing in Week 2. Now the 49ers will keep on rolling with Christian McCaffrey in the backfield.
The 49ers and Cardinals kick off at 4:25 p.m. ET.
Other injuries we are keeping an eye on ahead of Sunday’s Week 4 games: